RESEARCH ARTICLE


Clinical Relevance of Nanoparticle Induced Hyperthermia for Drug Delivery and Treatment of Abdominal Cancers



Nicole H. Levi-Polyachenko*, 1, John H. Stewart IV2
1 Wake forest University Health Sciences, Plastic and Reconstructive Surgery Department, Winston-Salem, NC, USA
2 Wake Forest University Health Sciences, Department of General Surgery, Section on Surgical Oncology, Winston-Salem, NC, USA

Article Information


Identifiers and Pagination:

Year: 2011
Volume: 3
First Page: 24
Last Page: 37
Publisher Id: TONMJ-3-24
DOI: 10.2174/1875933501103010024

Article History:

Received Date: 15/06/2010
Revision Received Date: 30/07/2010
Acceptance Date: 03/11/2010
Electronic publication date: 25/5/2011
Collection year: 2011

© 2011 Levi-Polyachenko and Stewart IV.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Wake forest University Health Sciences, Plastic and Reconstructive Surgery Department, Winston-Salem, NC, USA; Tel: 336-713-8052; Fax: 336-713-6524; E-mail: nlevi@wfubmc.edu


Abstract

The aim of this review is to introduce the reader to the potential clinical utility for the delivery of chemotherapy in the context of nanoparticles. We will present traditional methods of hyperthermia and then focus on the clinical technique for using intraperitoneal hyperthermic chemoperfusion for the treatment of peritoneal surface dissemination of colorectal cancer. Cellular mechanisms of hyperthermia as well as clinically effective chemotherapeutic agents are discussed. In the past decade carbon and metal nanoparticles have been explored for their ability to induce hyperthermia; however, many of these studies examine nanoparticles for tumor ablation at high temperatures. There are currently few studies that evaluate mild hyperthermia (below 43#x00B0;C) generated by nanoparticles to enhance the delivery of chemotherapeutic agents. The fundamentals for generation of hyperthermia from carbon and metal nanoparticles is discussed as are the limitations and benefits of specific nanoparticles with chemotherapeutic agents. This review will show that there is significant potential for the use of nanoparticles to induce hyperthermia and increase the delivery of chemotherapeutic agents for treatment of colorectal cancer and other peritoneal disease.

Keywords: Hyperthermia, Intraperitoneal Chemoperfusion, Nanoparticles.